| Rank Player | Opponent |
|---|---|
| 1. D. Adams GB WR | @SF |
| 2. D. Cook MIN RB | DET |
| 3. C. McCaffrey CAR RB | @KC |
| 4. K. Allen LAC WR | LV |
| 5. D. Hopkins ARI WR | MIA |
| 6. A. Kamara NO RB | @TB |
| 7. D. Metcalf SEA WR | @BUF |
| 8. J. Jones ATL WR | DEN |
| 9. T. Hill KC WR | CAR |
| 10. T. Kelce KC TE | CAR |
| 11. S. Diggs BUF WR | SEA |
| 12. A. Thielen MIN WR | DET |
| 13. J. Robinson JAC RB | HOU |
| 14. C. Edmonds ARI RB | MIA |
| 15. A. Robinson CHI WR | @TEN |
| 16. T. Lockett SEA WR | @BUF |
| 17. D. Henry TEN RB | CHI |
| 18. A. Brown TEN WR | CHI |
| 19. E. Elliott DAL RB | PIT |
| 20. D. Moore CAR WR | @KC |
| 21. T. McLaurin WAS WR | NYG |
| 22. J. Jacobs LV RB | @LAC |
| 23. J. Conner PIT RB | @DAL |
| 24. R. Anderson CAR WR | @KC |
| 25. C. Beasley BUF WR | SEA |
| 26. W. Fuller HOU WR | @JAC |
| 27. D. Waller LV TE | @LAC |
| 28. S. Shepard NYG WR | @WAS |
| 29. B. Cooks HOU WR | @JAC |
| 30. J. Dobbins BAL RB | @IND |
| 31. M. Evans TB WR | NO |
| 32. J. Smith-Schuster PIT | @DAL |
| 33. J. Jefferson MIN WR | DET |
| 34. D. Swift DET RB | @MIN |
| 35. B. Aiyuk SF WR | GB |
| 36. T. Gurley ATL RB | DEN |
| 37. C. Edwards-Helaire KC RB | CAR |
| 38. D. Johnson PIT WR | @DAL |
| 39. M. Andrews BAL TE | @IND |
| 40. M. Jones DET WR | @MIN |
| 41. E. Sanders NO WR | TB |
| 42. D. Johnson HOU RB | @JAC |
| 43. D. Harris NE RB | NYG |
| 44. J. Jackson LAC RB | LV |
| 45. C. Claypool PIT WR | @DAL |
| 46. T. Hockenson DET TE | @MIN |
| 47. A. Gibson WAS RB | NYG |
| 48. J. Hasty SF RB | GB |
| 49. A. Borwn TB WR | NO |
| 50. A. Cooper DAL WR | PIT |